Portfolio

A book of companies defining the future of the human condition.

Sector
Climate manufacturing · Advanced materials
Stage at entry
Seed
Status
Active
Web

Fiber Global

Reindustrializing American building materials with a recycled-feedstock process.

Fiber Global manufactures next-generation sustainable fiberboard from a recycled feedstock, displacing the formaldehyde-intensive incumbent through a process that sits structurally below the cost curve of any wood-based competitor. Mega Factory 1, the company’s second facility, opened in Brownsburg in August 2025.

Why we invested

An operator-led founding team executing factory build-outs at a tempo that incumbents cannot match. A structural cost advantage rooted in the input chemistry, not in marketing positioning. A long-term play on American manufacturing reindustrialization that compounds with each production line that comes online.

Sector
Space infrastructure
Stage at entry
Series A
Status
Active
Web

Vast

The first commercial successor to the ISS.

Vast is building commercial space stations to replace the ISS when NASA retires it at the end of the decade. Haven Demo, a 3-month in-orbit technology demonstration, concluded successfully on February 4, 2026. The company’s first commercial station, Haven-1, launches aboard SpaceX in 2027, on a six-month hardware cycle that out-paces the rest of the industry by years.

Why we invested

A founder with the conviction to fund hundreds of millions of dollars of his own capital through R&D. Alignment is total. A two-year hardware lead in a category where physics, not narrative, decides the winner. Hard, regulated, capital-intensive infrastructure with a defined re-rating moment as the post-ISS commercial era begins. Patient capital is exactly the right capital here.

Sector
Life sciences instrumentation · Microfluidics
Stage at entry
Pre-seed
Status
Active
Web

DP Bio

Droplet microfluidics for million-cell single-cell screens.

DP Bio builds droplet microfluidics platforms that encapsulate single cells into picoliter droplets, run fluorescence-based functional assays inside each one, and sort the positives at scale. The flagship instrument, CytoSpark, runs million-cell screens in a single day, compressing antibody discovery workflows that traditionally take months into one to two days. A five-instrument family extends the platform across single-cell sequencing, digital PCR, and extracellular vesicle analysis.

Why we invested

Founder caliber and scientific vision validated through years of close-quarters relationship. A defensible position in a real, contested category, where a well-engineered platform manufactured in Asia with active US distribution can take share against incumbents. Direct alignment with our life-sciences thesis: the same pharma, biotech, CRO, CDMO, and research accounts our operating partner already supplies are the natural buyers for CytoSpark and OMNIdrop instruments.

Sector
Neurotech · Foundation models
Stage at entry
Pre-seed
Status
Active
Web

MindFlow

A foundation model for EEG hardware.

MindFlow is building a foundation model for EEG hardware: a general-purpose neural signal layer that decodes brain activity across consumer and clinical headsets, providing the substrate that cognition-aware applications and adaptive software can be built on top of.

Why we invested

Two technically credible founders covering the two hardest surfaces of the product: signal processing and inference. Engineering rigor and a cognitive profile we trust to compound. A category that defines a future mode of human-machine interaction.

Sector
Life sciences instrumentation
Stage at entry
Seed
Status
Stealth

Stealth Biotech

Details under wraps.

Early-stage life sciences company operating in stealth. Further information is not publicly disclosed.

Why we invested

A founding team with prior exits in the same category, recruited entirely on reputation. Unique IP that defines a defensible position in a market the incumbents physically cannot serve. A long-term scientific bet on a problem the rest of the industry has left unsolved, backed by a credible, milestone-gated technical plan.

Building something that fits this profile? jesse [at] yanvc [dot] com